A Randomized, Single Blinded Study of the Augmentation of Anterior Cruciate Ligament Reconstruction using Stump-Derived Mesenchymal Stem Cells Versus Standard of Care Anterior Cruciate Ligament Reconstruction

The primary objective of this study is to develop a cost-effective, autologous biologic augmentation technique for ACL reconstruction. The technique involves applying tissue harvested with the GraftNet from the patient’s ACL stump to an ACL autograft. This study is key to determining a reproducible and effective autologous biologic augmentation technique that can be utilized at the point-of-care during ACL reconstruction surgery.

FTA results as well as measurements from MRI evaluation will be recorded and utilized to quantify the healing and ACL graft maturation processes. MRI evaluation will be performed in accordance with accepted ACL imaging protocols. This data will then be compared to FTA results and MRI evaluation from patients who did not undergo the bioaugmentation technique for ACL reconstruction.

Principal Investigator – Adam Anz, M.D.

Sponsored by Andrews Research & Education Foundation and the State of Florida, Department of Health

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